It is a list of each laboratory.
AIDS Research I
Professor:Masafumi Takiguchi
TAKIGUCHI Project Laboratory
We investigate the function of cytotoxic T cells (CTLs), mediators of HIV-1 control. We particularly focus on how CTLs suppress HIV-1, how HIV-1 escapes from their recognition, and how they evolve to suppress HIV-1 escape mutants (co-evolution of HIV and CTLs). Based on our discoveries, we are developing HIV-1 cure treatment. We also investigate HIV vaccine targeting conserved regions in collaboration with Dr. Tomas Hanke at the University of Oxford. In addition, we comparatively analyze the human leucocyte antigens class I molecules and HIV-specific CTLs worldwide by collaborating with Drs. Mary Carrington at NIH, Sarah Rowland-Jones at the University of Oxford, and Victor Appay at INSERM/ Sorbonne Universites. Additionally, we conduct a cohort study in Vietnam to study HIV-specific CTLs for a universal vaccine.
AIDS Research II
Professor:Shuzo Matsushita
Matsushita Project Laboratory
Our research aimed to develop new therapies for patients infected with HIV-1 and vaccines to prevent from HIV-1 infection. We have analyzed antibodies induced in patients infected with HIV-1, and developed genetically modified antibodies. In addition, we are challenging development of small molecules to enhance antibody function and therapy to eradicate residual viruses under anti-retroviral therapy.
AIDS Research III
Professor:Seiji Okada
OKADA Project Laboratory
Human Immunodeficiency Virus type 1 (HIV-1) is known to infect a variety of blood cells and influence the human immune and hematopoietic systems. Progress in the anti-HIV-1 therapy so called highly active antiretroviral therapy (HAART) has been successful in controlling HIV-1 infection and drastically improved the prognosis of HIV-1 patients. However, HAART cannot eliminate HIV-1 completely and even well controlled patients still have defects in immune system, which cause the AIDS-related malignancies. As the immune and hematopoietic systems are complex of diverse system, the analysis of the interaction between HIV-1 and these systems are crucial. In this program, we are going to clarify the interaction using in vitro culture system and mouse model especially focused on innate immunity (natural killer cells and macrophages) and hematopoietic stem cells. The goal of our study is to establish the control of HIV-1 infection by immune system.
AIDS Research IV
Professor:Shinya Suzu
SUZU Project Laboratory
Shinya Suzu and his group have focused on cells of the myeloid lineage that are composed of a wide array of cells and have various roles in immunity, inflammation, human diseases and viral infection including HIV-1. Their researches have revealed a new pathway that regulates the differentiation and function of myeloid cells, and have identified a unique interplay between the differentiation of these myeloid cells and the regulation of HIV-1 growth.
AIDS Research V
Associate Professor:Takamasa Ueno
UENO Project Laboratory
We have been interested in polymorphic nature of HIV-1 genes and proteins as well as their consequences to heterologous protein functions, viralreplication competency, viral immune evasion and disease progression in vivo. Specifically, our recent focus is on HIV-1 accessory genes andproteins such as Nef, Vpu, Vif and Vpr. A feature of our group is a largeand interactive intercontinental collaboration network comprising of USA, Canada, UK, Germany, Australia, China, South Africa, and beyond. Inaddition, we have recently initiated an implementing research at Tanzanialocated in Sub-Saharan Africa, most important HIV/AIDS epidemic region in the globe.
AIDS Research VII
Associate Professor:Yasuo Ariumi
ARIUMI Project Laboratory
We investigate the life cycle of retroelements, including human immunodeficiency virus type 1 (HIV-1), hepatitis B virus (HBV) and long interspersed element 1 (LINE-1, L1), and host factors involved in their life cycle. Indeed, we currently focus on the molecular mechanism(s) how these retroelemets integrate in the human genome. Furthermore, we also investigate novel HIV-1 restriction factors.
AIDS Research XIII
Associate Professor:Yorifumi Satou
SATOU Project Laboratory
Our lab’s research focuses on the two retroviruses known to cause human diseases, HIV and HTLV. We are using the latest approach in genomics and transcriptomics to elucidate the mechanism of persistent and latent infection of these retroviruses and identifying the epigenetic factors regulating the transcription of the integrated provirus.
AIDS Research IX
Visiting Professor:Shinichi Oka
OKA-GATANAGA Project Laboratory
My laboratory is conducting international cohort studies with developing countries. We have two counterparts. One is in Vietnam and the other in Mongolia. In Vietnam, we have been organizing an HIV patient cohort on ART that maintains over 2000 patients for more than 10 years. The number of patients on ART is rapidly increasing recently. There are so many issues to be resolved along with ART such as monitoring of efficacy and side effects, and co-infection of hepatitis. By using this cohort, we are conducting several clinical studies to answer them. In Mongolia, we have maintained an MSM cohort to monitor prevalence of HIV and STDs and superinfection of HBV in Mongolian MSM since 2014. If you have some interests in these clinical studies, please let me know.
OTHERS Laboratory
■AIDS Research VI / Undecided
■AIDS Research VIII / Undecided
■AIDS Research XI / Tetsuro Matano(Visiting Professor)
■AIDS Research XII / Kazuhisa Yoshimura(Visiting Associate Professor)